Order Trazodone Online in US Licensed Pharmacy For Insomnia

Trazodone is an antidepressant that belongs to a group of drugs called serotonin receptor antagonists and reuptake inhibitors (SARIs). While trazodone is not a true member of the selective serotonin reuptake inhibitors (SSRIs) class of antidepressants, it does still share many properties of the SSRIs.

Trazodone is used to treat major depressive disorder.

It may help to improve your mood, appetite, and energy level as well as decrease anxiety and insomnia related to depression.

Trazodone works by helping to restore the balance of a certain natural chemical (serotonin) in the brain.

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Trazodone, sold under many brand names, is an antidepressant medication, used to treat major depressive disorder, anxiety disorders, and insomnia. It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class. The medication is taken orally.

Common side effects include dry mouth, feeling faint, vomiting, and headache. More serious side effects may include suicide, mania, irregular heart rate, and pathologically prolonged erections. It is unclear if use during pregnancy or breastfeeding is safe. Trazodone also has sedating effects.

Trazodone was approved for medical use in the United States in 1981. It is available as a generic medication. In 2022, it was the eighteenth most commonly prescribed medication in the United States, with more than 27 million prescriptions

How it works

Trazodone is an antidepressant that may also be used to treat insomnia.
Experts aren’t sure exactly how trazodone works but suggest it improves the symptoms of depression by inhibiting the uptake of serotonin by nerves in the brain. This increases levels of serotonin in the nerve synapse (the space between two nerves).
Trazodone has a unique chemical structure and is unrelated to selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), or monoamine oxidase inhibitors (MAO inhibitors). It is structurally related to nefazodone. Trazodone and nefazodone belong to the class of drugs known as serotonin modulators. It may also be called a serotonin receptor antagonists and reuptake inhibitor (SARI).

Side Effects of Taking Trazodone

Trazodone is a medication commonly prescribed for depression, anxiety, and insomnia. While it can be effective for these conditions, it may also cause side effects. These can vary in severity and likelihood depending on the individual, dosage, and duration of use. Below are some common, less common, and serious side effects of trazodone:

Common Side Effects:

Drowsiness or Fatigue: Often used as a benefit for insomnia, but may interfere with daytime alertness.
Dry Mouth
Dizziness or Lightheadedness
Headache
Nausea or Vomiting
Constipation or Diarrhea
Blurred Vision
Weight Changes (gain or loss)
Sweating

Less Common Side Effects:

Nervousness or Anxiety
Muscle Pain
Tinnitus (Ringing in the Ears)
Nightmares or Vivid Dreams

Serious Side Effects (Seek Medical Attention):

Orthostatic Hypotension: A sudden drop in blood pressure when standing up, leading to dizziness or fainting.
Priapism: A rare but serious condition involving prolonged or painful erections (in men). This is a medical emergency.
Heart Rhythm Changes (Arrhythmias):
- Palpitations
- Prolonged QT interval on ECG (can be life-threatening in rare cases)
Serotonin Syndrome: Can occur if trazodone is combined with other medications affecting serotonin, such as SSRIs, SNRIs, or MAOIs.
- Symptoms: Agitation, confusion, rapid heart rate, high blood pressure, tremors, or fever.
Allergic Reactions:
- Rash, itching, swelling, severe dizziness, or difficulty breathing.
Liver or Kidney Problems:
- Symptoms: Yellowing of the skin/eyes (jaundice), dark urine, or persistent nausea/vomiting.
Suicidal Thoughts or Behavior: Particularly in younger adults (up to 24 years), trazodone can increase the risk of these symptoms early in treatment.

Tips to Minimize Side Effects:

Take trazodone at bedtime to reduce drowsiness during the day.
Avoid alcohol, as it can amplify drowsiness and dizziness.
Stay hydrated to help with dry mouth and constipation.
Stand up slowly to prevent dizziness or fainting from low blood pressure.
Inform your doctor about all medications you’re taking to avoid interactions.

When to Contact a Doctor:

If side effects are persistent, severe, or interfere with daily life.
If you experience symptoms of serotonin syndrome, priapism, or significant changes in mood or behavior.

Would you like guidance on managing specific side effects or more detailed information on a particular concern?

Before Taking Trazodone

You should not use trazodone if you are allergic to it.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

After you stop taking trazodone, you must wait at least 14 days before you start taking an MAOI.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with trazodone could cause a serious condition called serotonin syndrome.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

liver or kidney disease;
heart disease, or a recent heart attack;
a bleeding or blood clotting disorder;
seizures or epilepsy;
narrow-angle glaucoma;
long QT syndrome;
drug addiction or suicidal thoughts; or
bipolar disorder (manic depression).

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking trazodone during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop this medicine without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trazodone on the baby.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

Trazodone is not approved for use by anyone younger than 18 years old.

How is trazodone supplied (dosage forms)?

Trazodone is available in the following dosage forms that are taken by mouth.

Usual Adult Dose for Depression:

Initial dose: 150 mg orally per day in divided doses; this may be increased by 50 mg orally per day every 3 to 4 days
Maximum dose:

-Inpatients: 600 mg/day
-Outpatients: 400 mg/day

Comments:

-Patients should be screened for a personal/family history of bipolar disorder, mania, or hypomania prior to initiating treatment.
-Patients should be monitored for withdrawal symptoms when discontinuing therapy.
-After an adequate response has been reached, dosage may be gradually reduced depending on therapeutic response.
-If drowsiness develops, a major portion of the daily dose may be administered at bedtime or a reduction of dosage may be necessary.

-This drug should be taken shortly after a meal or light snack.

50 mg tablets
100 mg tablets
150 mg tablets
300 mg tablets

Trazodone Usages

Trazodone is an antidepressant primarily classified as a serotonin antagonist and reuptake inhibitor (SARI). It is FDA-approved for the following condition:

Major Depressive Disorder (MDD)
- Trazodone is used to treat depression by helping to improve mood, energy levels, and overall well-being. It works by balancing serotonin levels in the brain.

Off-Label Uses of Trazodone

Trazodone is widely prescribed for several off-label purposes, often taking advantage of its sedative properties. These include:

Insomnia
- Due to its sedative effects, trazodone is often used to help people with difficulty sleeping, especially when other medications or lifestyle changes are ineffective.
Anxiety Disorders
- It may be prescribed for generalized anxiety disorder (GAD) or other forms of anxiety to promote calmness and reduce stress.
Chronic Pain Management
- Trazodone can be used in conjunction with other therapies to help with pain syndromes, including fibromyalgia and chronic pain, by improving sleep and reducing associated depression.
Post-Traumatic Stress Disorder (PTSD)
- In some cases, trazodone is used to help manage the sleep disturbances and intrusive symptoms associated with PTSD.
Agitation in Dementia
- It may be prescribed to elderly patients to manage behavioral symptoms associated with dementia, such as agitation or aggression.
Panic Disorder
- Trazodone’s calming effects can also benefit those suffering from panic attacks or panic disorders.
Nightmares and Parasomnias
- It has been used to reduce the frequency and intensity of nightmares, particularly in individuals with PTSD.
Alcohol Dependence
- In certain cases, trazodone is prescribed to help with sleep and mood stabilization during alcohol withdrawal or recovery phases.
Restless Leg Syndrome (RLS)
- Though less common, it can help manage the symptoms of RLS by improving sleep quality.

What special precautions should I follow?

Before taking trazodone,

tell your doctor and pharmacist if you are allergic to trazodone or any other medications.
tell your doctor or pharmacist if you are taking the following medications or stopped taking them within the past two weeks: monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), linezolid, methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Your doctor will probably tell you that you should not take trazodone. If you stop taking trazodone, your doctor will tell you that you should wait at least 14 days before you start to take an MAO inhibitor.
some medications should not be taken with trazodone. Other medications may cause dosing changes or extra monitoring when taken with trazodone. Make sure you have discussed any medications you are currently taking or plan to take before starting trazodone with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking trazodone, please get the advice of your doctor or pharmacist.
the following nonprescription or herbal products may interact with trazodone: St. John’s wort; tryptophan; aspirin and other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve). Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking trazodone. Do not start any of these medications while taking trazodone without discussing with your healthcare provider.
tell your doctor if you or anyone in your family has or has ever had long QT syndrome (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), if you have ever had a heart attack, or if you have a low level of sodium in your blood. Also tell your doctor if you drink or have ever drunk large amounts of alcohol, or if you have or have ever had high blood pressure; bleeding problems; sickle cell anemia (a disease of the red blood cells); multiple myeloma (cancer of the plasma cells); leukemia (cancer of the white blood cells); cavernosal fibrosis or Peyronie’s disease (conditions that affects the shape of the penis such as angulation); or heart, liver, or kidney disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking trazodone, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking trazodone.
you should know that trazodone may make you drowsy and affect your judgment, thinking, and movements. Do not drive a car or operate machinery until you know how this medication affects you.
ask your doctor about the safe use of alcoholic beverages while you are taking trazodone. Alcohol can make the side effects from trazodone worse.
you should know that trazodone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
you should know that trazodone may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

What special dietary instructions should I follow?

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What should I tell my healthcare provider before using trazodone?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if trazodone is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.

Heart conditions, including a family history of QT prolongation (a rare dangerous heart rhythm problem)
History of heart attack
Bipolar disorder or mania
Liver or kidney problems
Glaucoma
Bleeding problems
Low sodium levels
Peyronie’s disease
Sickle cell anemia, multiple myeloma, leukemia, or other serious medical conditions

Pregnancy. It is not known if or how trazodone could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take trazodone while you are pregnant or trying to get pregnant.

Breastfeeding. Trazodone may pass into your breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take trazodone while breastfeeding.

Does trazodone interact with foods or drinks?

There are no known interactions between trazodone and foods or drinks.

Do not drink alcohol while taking trazodone. The risk of dizziness or sleepiness may be increased if you drink alcohol while taking trazodone.

Does trazodone interact with other medicines (drug interactions)?

Using trazodone with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your current medicines. Many drugs can interact with trazodone, especially:

any other antidepressants;
phenytoin;
St. John’s wort;
tramadol;
a diuretic or “water pill”;
medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia;
a blood thinner – warfarin, Coumadin, Jantoven; or
migraine headache medicine – sumatriptan, Imitrex, Maxalt, Treximet, and others.

This list is not complete and many other drugs may interact with trazodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

How long does it take for trazodone to work?

Trazodone may start to relieve depression 1 to 2 weeks after you begin taking it, but it can take up to 6 weeks for the full benefit of the medication to set in.

If your doctor prescribed trazodone for depression, you should not assume that the treatment is ineffective until you’ve given it the full 6 weeks to work.

However, in the first few weeks of treatment, some patients may experience a worsening of symptoms. If you have thoughts of self-harm or suicide while waiting for the treatment to start working, you should talk to your doctor immediately.

Some people may feel drowsy after taking trazodone, so it’s recommended to take it at bedtime.

You should also contact your doctor if you’re experiencing unpleasant symptoms or signs of adverse effects while taking trazodone, such as:

An irregular heartbeat (arrhythmia)
Symptoms of serotonin syndrome (agitation, hallucination, dizziness, tremor, nausea)
An erection lasting more than 4 hours (for men)

Consult your doctor before stopping treatment with trazodone. Sudden discontinuation of trazodone can cause withdrawal, which comes with symptoms including insomnia, agitation and anxiety. If you want to stop taking trazodone, your doctor will help you taper off the medication safely, taking gradually lower doses.