What Are Gabapentinoids?

Gabapentinoids include gabapentin and pregabalin. They are FDA-approved to treat a variety of conditions including partial seizures; pain from damaged nerves that follows spinal cord injury, healing of shingles, or diabetes; fibromyalgia; and moderate to severe primary restless legs syndrome. Gabapentin is marketed under the brand names Neurontin and Gralise, and as generics. Gabapentin enacarbil … Read more

How Does Gabapentin Work ?

In people with partial seizures, gabapentin works by decreasing abnormal activity in the brain. Experts believe gabapentin may cause brain cells to produce more of a chemical called GABA, which reduces abnormal electrical activity of brain cells. In people experiencing nerve pain after having had shingles, gabapentin is thought to change the way pain signals … Read more

Gabapentin Information for Patients and Caregivers

Gabapentin is an anticonvulsant (antiseizure) medication approved by the FDA to treat several conditions. Doctors sometimes prescribe gabapentin “off-label” to treat other conditions as well. A 2022 report stated that gabapentin was among the 10 most commonly prescribed medications in the U.S. What is gabapentin and what is it used for? Gabapentin is used to … Read more

Potential Side Effects of Taking Gabapentin

Gabapentin is taken by mouth and available as a capsule, tablet, or liquid. Dosages range from 300 to 3600 milligrams (mg) a day, though they are often adjusted for children, older people, and those with kidney disease. The medication is available as an immediate-release oral tablet, an extended-release oral tablet, and an oral solution. It can … Read more

NEURONTIN (Gabapentin) Overdose Symptoms, Treatment , and Prevention

A lethal dose of gabapentin was not identified in mice and rats receiving single oral doses as high as 8000 mg/kg. Signs of acute toxicity in animals included ataxia, labored breathing, ptosis, sedation, hypoactivity, or excitation. Acute oral overdoses of NEURONTIN up to 49 grams have been reported. In these cases, double vision, slurred speech, … Read more